Research Article Ki-67 Expression in CRC Lymph Node Metastasis Does Not Predict Survival
نویسندگان
چکیده
1Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus of Gualtar, 4710-057 Braga, Portugal 2ICVS/3B’s-PT Government Associate Laboratory, Braga/Guimarães, Campus of Gualtar, 4710-057 Braga, Portugal 3Surgery Department, Hospitalar Center Trás-os-Montes e Alto Douro, Unidade Hospitalar de Chaves, Avenida Dr. Francisco Sá Carneiro, 5400-279 Chaves, Portugal 4Pathology Department, Braga Hospital, Sete Fontes, São Victor, 4710-243 Braga, Portugal 5Coloproctology Unit, Braga Hospital, Sete Fontes, São Victor, 4710-243 Braga, Portugal 6Laboratory of Medical Investigation (LIM) 14, Faculty of Medicine, University of Sao Paulo, 01246-903 São Paulo, SP, Brazil 7Molecular Oncology Research Centre, 14784-400 Barretos, SP, Brazil
منابع مشابه
Ki-67 Expression in CRC Lymph Node Metastasis Does Not Predict Survival
Colorectal cancer is one of the most common malignancies and a leading cause of cancer death worldwide. Molecular markers may improve clinicopathologic staging and provide a basis to guide novel therapeutic strategies which target specific tumour-associated molecules according to individual tumour biology; however, so far, no ideal molecular marker has been found to predict disease progression....
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Recent studies display that Leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5) appears to involve the initiation of colorectal cancer (CRC). However, its role in the progression of CRC is not clear at present. In the present study, the expression of Lgr5, HER2, VEGF, and Ki-67 was detected by immunohistochemistry in primary cancer tissue and the matched normal mucosa, metastatic...
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